La Quinta is situated approximately 150 miles northeast of San Diego and 130 miles east of Los Angeles on the desert floor of the Coachella Valley.

Directions from San Diego County:
- I-15 N toward Riverside
- Exit CA-79 S toward Indio (Temecula Parkway)
- L on CA-371 (Cahuilla Rd)
- R on CA-74 E (Palm to Pines Hwy)
- R on Highway 111
- R on Jefferson St.
- Jefferson turns into PGA West Blvd at Ave. 54
- R on Arnold Palmer (Entry Gate)

Directions from Los Angeles County:
- I-10 E toward Palm Springs
- Exit Indio Blvd (exit 139)
- R onto Jefferson St.
- Jefferson turns into PGA West Blvd at Ave. 54
- R on Arnold Palmer (Entry Gate)

Directions from Orange County:
- CA-91 E toward Riverside
- Merge onto CA-60 E (shared with I-215 S)
- Continue on CA-60 E after I-215 split
- Merge onto I-10 E
- Exit Indio Blvd (exit 139)
- R onto Jefferson St.
- Jefferson turns into PGA West Blvd at Ave. 54
- R on Arnold Palmer (Entry Gate)